The Sixt rent-a-car station Berlin Friedrichshain/Treptow is located inside of the Treptowers and really close to Mediaspree. It's just a short walk from the Sixt-Station to the Treptower Park. There you can go for a nice walk or you can start a sightseeing trip by boat with Stern- und Kreisschiffahrten. Many event locations are also around this station, e.g. Club der Visionäre, Arena, O2-World. Berlin sightseeing points, like Alexanderplatz, Friedrichstraße, Checkpoint Charlie, Brandenburger Tor, Kurfürstendamm (Kudamm), are easily to reach by car. We would recommend a GPS, which you can rent in this station, for an enjoyable road trip through Berlin.
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